The Urgent Need for Broad-Spectrum Antiviral Drugs
نویسندگان
چکیده
منابع مشابه
Antiviral drug discovery: broad-spectrum drugs from nature.
Covering: up to April 2014. The development of drugs with broad-spectrum antiviral activities is a long pursued goal in drug discovery. It has been shown that blocking co-opted host-factors abrogates the replication of many viruses, yet the development of such host-targeting drugs has been met with scepticism mainly due to toxicity issues and poor translation to in vivo models. With the advent ...
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Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics. Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular defense system. High throughput screening of molecules, genetic engineering of peptides, and functional screening of agents have identified promi...
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Mucus is a porous biopolymer matrix that coats all wet epithelia in the human body and serves as the first line of defense against many pathogenic bacteria and viruses. However, under certain conditions viruses are able to penetrate this infection barrier, which compromises the protective function of native mucus. Here, we find that isolated porcine gastric mucin polymers, key structural compon...
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O ver the last 20 years, important advances have been made in the clinical use of oral anticoagulants and in our understanding of their mechanism of action. Clinical trials have demonstrated that oral anticoagulants are effective antithrombotic agents,' that the incidence of bleeding is influenced strongly by the intensity of the anticoagulant effect,2-S and that for many clinical indications t...
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ژورنال
عنوان ژورنال: Journal of Human Virology & Retrovirology
سال: 2015
ISSN: 2373-6453
DOI: 10.15406/jhvrv.2015.02.00032